LncRNAs: The Regulator of Glucose and Lipid Metabolism in Tumor Cells

Frontiers in Oncology

Xiumei Sheng¹  Jie Ma¹  Shengjun Wang¹  Wei Lu¹  Fenghua Cao² 

[1] Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China;Zhenjiang Hospital of Chinese Traditional and Western Medicine, Zhenjiang, China;

关键词: lncRNAs;    tumor;    glucose;    lipid;    metabolism;    therapy;   

DOI  :  10.3389/fonc.2019.01099

来源: DOAJ

【 摘 要 】

Metabolism is a complex network of regulatory system. Cells often alter their metabolism in response to the changes in their environment. These adaptive changes are particularly pronounced in tumor cells, known as metabolic reprogramming. Metabolic reprogramming is considered to be one of the top 10 characteristics of tumor cells. Glucose and lipid metabolism are important components of metabolic reprogramming. A large number of experimental studies have shown that long non-coding RNAs (lncRNAs) play an important role in glucose and lipid metabolism. The current review briefly introduces the regulatory effect of lncRNAs on glucose and lipid metabolism of tumor cells, and the significance of lncRNA-mediated metabolism in tumor therapy, hoping to provide new strategies for clinical targeting tumor therapy.

【 授权许可】

Unknown