Plasma Profiles of Glucose, Insulin and Lipids in the Male WBN/Kob-Leprfa Rat, a New Model of Type 2 Diabetes with Obesity

Journal of Veterinary Medical Science

Haruya ISHIZAWA²  Fumitoshi ASAI²  Akira OKUNO¹  Kanako OHNO-ICHIKI¹  Mitsuyuki SHIRAI²  Noriyuki KAJI²  Hisako OKI² 

[1] Shinagawa R&D Center, Daiichi-Sankyo Co., Ltd., 1–2–58 Hiromachi, Shinagawa-ku, Tokyo 140–8710, Japan;Department of Pharmacology, Azabu University School of Veterinary Medicine, 1–17–71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252–5201, Japan

关键词: glucose;    insulin;    lipid;    type 2 diabetes;    WBN/Kob-Leprfa rat;   

DOI  :  10.1292/jvms.12-0045

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(16)Cited-By(2)Plasma profiles of glucose, insulin and lipids were examined in the male WBN/Kob-Leprfa (fa/fa) rat, a new model of type 2 diabetes (T2D), in comparison with age-matched original male WBN/Kob (lean) rats. The fa/fa rats developed hypertriglycemia, obesity and hyperglycemia from 5, 7, and 9 weeks of age, respectively. Plasma insulin levels in fa/fa rats were significantly higher than those in lean rats at 5 weeks of age, but after 11 weeks of age gradually declined to the levels in lean rats. HOMA-IR, a measure of insulin resistance status, showed that fa/fa rats had insulin resistance. The fa/fa rat has the potential to become an important animal model of T2D with obesity.

【 授权许可】

Unknown