Sesame oil lignans inhibit hepatic endoplasmic reticulum stress and apoptosis in high-fat diet-fed mice

Journal of Functional Foods

Minji Woo¹  Yeong Ok Song¹  Mijeong Kim¹  Jeong Sook Noh²  Eunok Choe³ 

[1] Department of Food Science and Nutrition and Kimchi Research Institute, Pusan National University, Busan 46241, Republic of Korea;Department of Food Science and Nutrition, Tongmyong University, Busan 48520, Republic of Korea;Department of Food and Nutrition, Inha University, Incheon 22212, Republic of Korea;

关键词: Sesame oil;    Lignan;    Endoplasmic reticulum stress;    Unfolded protein response;    Apoptosis;   

DOI  :  

来源: DOAJ

【 摘 要 】

The inhibitory effect of lignan-rich sesame oil (SSO) against the endoplasmic reticulum (ER) stress and apoptosis induced by a high-fat diet (HFD) was studied, and its mechanism of action was elucidated in a comparison with soybean oil (SBO), which contains similar unsaturated fatty acid content but has no lignans. The HFD was prepared by adding 20% (w/w) lard (LD), SSO, or SBO to chow diet and provided for 12 weeks. In the SSO group, expression of ER stress and proapoptotic markers were downregulated, compared with levels in the LD group. However, these effects were not observed in the SBO group. The hepatic triacylglycerol concentration and expression of lipogenic enzyme in the SSO group were lower than that in the LD and SBO groups. These results show that SSO is able to decrease HFD-induced ER stress and apoptosis, and these effects were likely caused by its lignan compounds.

【 授权许可】

Unknown