Ocular biomarkers for cognitive impairment in nonagenarians; a prospective cross-sectional study

BMC Geriatrics

Pieter Jelle Visser¹  Maryam Badissi¹  Jori Tomassen¹  Nienke Legdeur¹  Anouk den Braber¹  Elles Konijnenberg¹  Mara ten Kate¹  Andrea B. Maier²  Frank D. Verbraak³  H. Stevie Tan³  H. Ton Nguyen³  Jacoba A. van de Kreeke³ 

[1] Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC;Department of Medicine and Aged Care, @AgeMelbourne, Royal Melbourne Hospital, University of Melbourne;Ophthalmology Department, Amsterdam UMC, location VUmc;

关键词: Retina;    Optical coherence tomography;    Fundus photography;    Singapore I vessel assessment;    Nonagenarians;    Ocular biomarkers;   

DOI  :  10.1186/s12877-020-01556-1

来源: DOAJ

【 摘 要 】

Abstract Background Ocular imaging receives much attention as a source of potential biomarkers for dementia. In the present study, we analyze these ocular biomarkers in cognitively impaired and healthy participants in a population aged over 90 years (= nonagenarian), and elucidate the effects of age on these biomarkers. Methods For this prospective cross-sectional study, we included individuals from the EMIF-AD 90+ study, consisting of a cognitively healthy (N = 67) and cognitively impaired group (N = 33), and the EMIF-AD PreclinAD study, consisting of cognitively healthy controls aged ≥60 (N = 198). Participants underwent Optical Coherence Tomography (OCT) and fundus photography of both eyes. OCT was used to asses total and individual inner retinal layer thickness in the macular region (Early Treatment Diabetic Retinopathy Study circles) as well as peripapillary retinal nerve fiber layer thickness, fundus images were analyzed with Singapore I Vessel Assessment to obtain 7 retinal vascular parameters. Values for both eyes were averaged. Differences in ocular biomarkers between the 2 nonagenarian groups were analyzed using linear regression, differences between the individual nonagenarian groups and controls were analyzed using generalized estimating equations. Results Ocular biomarkers did not differ between the healthy and cognitively impaired nonagenarian groups. 19 out of 22 ocular biomarkers assessed in this study differed between either nonagenarian group and the younger controls. Conclusion The ocular biomarkers assessed in this study were not associated with cognitive impairment in nonagenarians, making their use as a screening tool for dementing disorders in this group limited. However, ocular biomarkers were significantly associated with chronological age, which were very similar to those ascribed to occur in Alzheimer’s Disease.

【 授权许可】

Unknown