Synthesis and in Vitro Antimicrobial Evaluation of NewN-Heterocyclic Diquaternary Pyridinium Compounds

Molecules

Martine Demeunynck¹  Bianca Furdui²  Rodica Mihaela Dinica²  Georgiana Parfene³  Ioana Otilia Ghinea³  Gabriela Bahrim³ 

[1] Centre National de la Recherche Scientifique (CNRS), UMR 5063, Department of Molecular Pharmacochemistry, F-38041 Grenoble, France;Department of Chemistry, Physics and Environment, Faculty of Science and Environment, "Dunarea de Jos" University of Galati, 111 Domneasca Street, 800201 Galati, Romania;Department of Food Science, Food Engineering and Applied Biotechnology, Faculty of Food Science and Engineering, "Dunarea de Jos" University of Galati, 111 Domneasca Street,800201 Galati, Romania;

关键词: pyridinium quaternary salts;    antimicrobial activity;    4-[2-(pyridin-4-yl)ethyl]pyridine, 4,4'-bipyridine;   

DOI  :  10.3390/molecules190811572

来源: DOAJ

【 摘 要 】

A series of bis-pyridinium quaternary ammonium salts (bis-PyQAs) with different aryl and heteroaryl moieties were synthesized and their antimicrobial activity investigated. The inhibition effect of the compounds was evaluated against bacteria, molds and yeasts; the activities were expressed as the minimum inhibitory concentrations (MIC). The relationships between the structure descriptors (logP, polarizability, polar surface area (2D), van der Waals area (3D)) and the biological activity of the tested bis-PyQAsare discussed.

【 授权许可】

Unknown