Synthesis and in Vitro Antimicrobial Evaluation of New N-Heterocyclic Diquaternary Pyridinium Compounds

Molecules

Bianca Furdui²  Georgiana Parfene¹  Ioana Otilia Ghinea¹  Rodica Mihaela Dinica²  Gabriela Bahrim¹ 

[1] Department of Food Science, Food Engineering and Applied Biotechnology, Faculty of Food Science and Engineering, “Dunarea de Jos” University of Galati, 111 Domneasca Street, 800201 Galati, Romania; E-Mails:;Department of Chemistry, Physics and Environment, Faculty of Science and Environment, “Dunarea de Jos” University of Galati, 111 Domneasca Street, 800201 Galati, Romania; E-Mail:

关键词: pyridinium quaternary salts;    antimicrobial activity;    4-[2-(pyridin-4-yl)ethyl]pyridine;    4;    4'-bipyridine;   

DOI  :  10.3390/molecules190811572

来源: mdpi

【 摘 要 】

A series of bis-pyridinium quaternary ammonium salts (bis-PyQAs) with different aryl and heteroaryl moieties were synthesized and their antimicrobial activity investigated. The inhibition effect of the compounds was evaluated against bacteria, molds and yeasts; the activities were expressed as the minimum inhibitory concentrations (MIC). The relationships between the structure descriptors (logP, polarizability, polar surface area (2D), van der Waals area (3D)) and the biological activity of the tested bis-PyQAs are discussed.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.