Connecting the Dots Between Inflammatory Bowel Disease and Metabolic Syndrome: A Focus on Gut-Derived Metabolites

Nutrients

Andrea Verdugo-Meza¹  Jiayu Ye¹  Hansika Dadlani¹  Sanjoy Ghosh¹  Deanna L. Gibson¹ 

[1] Department of Biology, University of British Columbia, Okanagan campus, Kelowna, British Columbia, V6T 1Z4, Canada;

关键词: immunometabolism;    gut microbiome;    microbiomics;    insulin resistance;    metabolism;    inflammatory bowel disease;   

DOI  :  10.3390/nu12051434

来源: DOAJ

【 摘 要 】

The role of the microbiome in health and disease has gained considerable attention and shed light on the etiology of complex diseases like inflammatory bowel disease (IBD) and metabolic syndrome (MetS). Since the microorganisms inhabiting the gut can confer either protective or harmful signals, understanding the functional network between the gut microbes and the host provides a comprehensive picture of health and disease status. In IBD, disruption of the gut barrier enhances microbe infiltration into the submucosae, which enhances the probability that gut-derived metabolites are translocated from the gut to the liver and pancreas. Considering inflammation and the gut microbiome can trigger intestinal barrier dysfunction, risk factors of metabolic diseases such as insulin resistance may have common roots with IBD. In this review, we focus on the overlap between IBD and MetS, and we explore the role of common metabolites in each disease in an attempt to connect a common origin, the gut microbiome and derived metabolites that affect the gut, liver and pancreas.

【 授权许可】

Unknown