Prophylactic effect of topical (slow-release) and systemic curcumin nano-niosome antioxidant on oral cancer in rat

BMC Complementary Medicine and Therapies

Hassan Bardania¹  Mahdieh-Sadat Moosavi²  Soussan Irani³  Bita Rohani⁴  Behzad Fazli⁵ 

[1] Cellular and Molecular Research Center, Yasuj University of Medical Sciences;Dental Research Center, Dentistry Research Institute, Department of Oral and Maxillofacial Medicine, Faculty of Dentistry, Tehran University of Medical Sciences;Dental Research Centre, Oral Pathology Department, Dental Faculty, Hamadan University of Medical Sciences;Department of Oral Medicine, Faculty of Dentistry, Aja University of Medical Sciences;Student Research Committee, Faculty of Dentistry, Aja University of Medical Sciences;

关键词: Antioxidant;    Curcumin;    Niosome;    Oral cancer;    Oxidant;   

DOI  :  10.1186/s12906-022-03590-5

来源: DOAJ

【 摘 要 】

Abstract Background Oral malignancies have a significant effect on the quality of life among the affected patients. Curcumin is an antioxidant with a low bioavailability in the target tissue. Niosomes are carriers of increasing the therapeutic effects of drugs and reducing their side effects. This study aimed to determine the effective dose of curcumin niosome in the culture and then to compare its prophylactic effect in the form of mouthwash with that of its injectable form on oral cancer in rats. Methods This was an in-vitro and in-vivo study. Firstly, KB oral cancer cells and human umbilical vein endothelial cells (HUVEC) were treated in separate groups with free curcumin, curcumin-loaded niosomes, and the unloaded niosomes at four doses of 4, 8, 16, and 32 μg. The study rats were then divided into the following four groups: 1) no intervention, 2) only carcinogenic substance, 3) carcinogenic substance with curcumin-loaded niosome injection, and 4) carcinogenic substance with a mouthwash containing niosome. Results At the cellular level, a dose of 16 μg after 24 h was selected as an effective dose. In the animal phase, the use of injectable curcumin niosome was observed to significantly prevent the development of severe forms of dysplasia. Conclusions In this in-vitro and in-vivo study, curcumin-loaded niosome was effective in preventing the development of severe forms of dysplasia and the inhibition of the growth of cancer cells.

【 授权许可】

Unknown