Changes in Mitochondrial Genome Associated with Predisposition to Atherosclerosis and Related Disease

Biomolecules

Andrey Grechko¹  Alexander Orekhov²  Shaw-Fang Yet³  Aleksandrina Volobueva⁴  Igor Sobenin⁵ 

[1] Federal Scientific Clinical Center for Resuscitation and Rehabilitation, Moscow 109240, Russia;Institute for Atherosclerosis Research, Skolkovo Innovative Center, Moscow 121609, Russia;Institute of Cellular and System Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 35053, Taiwan;Laboratory of Gene Therapy, Biocad Biotechnology Company, Saint-Petersburg, Strelnya 198515, Russia;Laboratory of Medical Genetics, Russian Cardiology Research and Production Complex, Moscow, Russia;

关键词: atherosclerosis;    mitochondria;    mtDNA;    mutations;    heteroplasmy;    molecular markers;   

DOI  :  10.3390/biom9080377

来源: DOAJ

【 摘 要 】

Atherosclerosis-related cardiovascular diseases remain the leading cause of morbidity and mortality, and the search for novel diagnostic and therapeutic methods is ongoing. Mitochondrial DNA (mtDNA) mutations associated with atherosclerosis represent one of the less explored aspects of the disease pathogenesis that may bring some interesting opportunities for establishing novel molecular markers and, possibly, new points of therapeutic intervention. Recent studies have identified a number of mtDNA mutations, for which the heteroplasmy level was positively or negatively associated with atherosclerosis, including the disease at its early, subclinical stages. In this review, we summarize the results of these studies, providing a list of human mtDNA mutations potentially involved in atherosclerosis. The molecular mechanisms underlying such involvement remain to be elucidated, although it is likely that some of them may be responsible for the increased oxidative stress, which plays an important role in atherosclerosis.

【 授权许可】

Unknown