Functional Connectivity at Rest between the Human Medial Posterior Parietal Cortex and the Primary Motor Cortex Detected by Paired-Pulse Transcranial Magnetic Stimulation

Brain Sciences

Sara Borgomaneri¹  Rossella Breveglieri²  Patrizia Fattori²  Matteo Filippini²  Marina De Vitis²  Alessia Tessari³ 

[1] Center for Studies and Research in Cognitive Neuroscience, University of Bologna, 47521 Cesena, Italy;Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy;Department of Psychology “Renzo Canestrari”, University of Bologna, 40127 Bologna, Italy;

关键词: medial posterior parietal cortex;    functional connectivity;    transcranial magnetic stimulation;    paired pulse stimulation;    parieto-M1 network;   

DOI  :  10.3390/brainsci11101357

来源: DOAJ

【 摘 要 】

The medial posterior parietal cortex (PPC) is involved in the complex processes of visuomotor integration. Its connections to the dorsal premotor cortex, which in turn is connected to the primary motor cortex (M1), complete the fronto-parietal network that supports important cognitive functions in the planning and execution of goal-oriented movements. In this study, we wanted to investigate the time-course of the functional connectivity at rest between the medial PPC and the M1 using dual-site transcranial magnetic stimulation in healthy humans. We stimulated the left M1 using a suprathreshold test stimulus to elicit motor-evoked potentials in the hand, and a subthreshold conditioning stimulus was applied over the left medial PPC at different inter-stimulus intervals (ISIs). The conditioning stimulus affected the M1 excitability depending on the ISI, with inhibition at longer ISIs (12 and 15 ms). We suggest that these modulations may reflect the activation of different parieto-frontal pathways, with long latency inhibitions likely recruiting polisynaptic pathways, presumably through anterolateral PPC.

【 授权许可】

Unknown