Predicting Long-Term After-Effects of Theta-Burst Stimulation on Supplementary Motor Network Through One-Session Response

Frontiers in Neuroscience

Tongjian Bai²  Chunyan Zhu²  Pingping Liu²  Xingqi Wu²  Kai Wang²  Dandan Li²  Jinmei Sun²  Yanghua Tian²  Fengqiong Yu²  Lei Zhang²  Junjie Wei²  Gong-Jun Ji⁴ 

[1] Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China;Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, China;Department of Medical Psychology, Chaohu Clinical Medical College, Anhui Medical University, Hefei, China;Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China;

关键词: continuous theta-burst stimulation;    functional connectivity;    magnetic resonance imaging;    transcranial magnetic stimulation;    supplementary motor area;   

DOI  :  10.3389/fnins.2020.00237

来源: DOAJ

【 摘 要 】

To understand the neural mechanism of repetitive transcranial magnetic stimulation (rTMS), the after-effects following one session or multiple days of stimulation have been widely investigated. However, the relation between the short-term effect (STE) and long-term effect (LTE) of rTMS is largely unknown. This study aims to explore whether the after-effects of 5-day rTMS on supplementary motor area (SMA) network could be predicted by one-session response. A primary cohort of 38 healthy participants underwent five daily sessions of real or sham continuous theta-burst stimulation (cTBS) on the left SMA. Resting-state functional magnetic resonance imaging (fMRI) data were acquired at the first (before and after the first stimulation) and sixth experimental day. The SMA connectivity changes after the first cTBS and after 5 days of stimulation were defined as STE and LTE, respectively. Compared to the baseline, significant STE and LTE were found in the bilateral paracentral gyrus (ParaCG) after real stimulation, suggesting shared neural correlates of short- and long-term stimulations. Region-of-interest analysis indicated that the resting-state functional connectivity between SMA and ParaCG increased after real stimulation, while no significant change was found after sham stimulation. Leave-one-out cross-validation indicated that the LTE in ParaCG could be predicted by the STE after real but not sham stimulations. In an independent cohort, the after-effects of rTMS on ParaCG and short- to long-term prediction were reproduced at the region-of-interest level. These imaging evidences indicate that one-session rTMS can aid to predict the regions responsive to long-term stimulation and the individualized response degree.

【 授权许可】

Unknown