Stimulating the hippocampal posterior-medial network enhances task-dependent connectivity and memory

eLife

Molly S Hermiller¹  Joel L Voss¹  Aneesha S Nilakantan¹  Kristen N Warren¹ 

[1] Interdepartmental Neuroscience Program, Department of Medical Social Sciences, Ken and Ruth Davee Department of Neurology, and Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, United States;

关键词: episodic memory;    functional connectivity;    autobiographical memory;    resting state;    transcranial magnetic stimulation;   

DOI  :  10.7554/eLife.49458

来源: DOAJ

【 摘 要 】

Successful episodic memory involves dynamic increases in activity across distributed hippocampal networks, including the posterior-medial (PMN) and the anterior-temporal (ATN) networks. We tested whether this up-regulation of functional connectivity during memory processing can be enhanced within hippocampal networks by noninvasive stimulation, and whether such task-dependent connectivity enhancement predicts memory improvement. Participants received stimulation targeting the PMN or an out-of-network control location. We compared the effects of stimulation on fMRI connectivity during an autobiographical retrieval task versus during rest within the PMN and the ATN. PMN-targeted stimulation significantly increased connectivity during autobiographical retrieval versus rest within the PMN. This effect was not observed in the ATN, or in either network following control stimulation. Task-dependent increases in connectivity within the medial temporal lobe predicted improved performance of a separate episodic memory test. It is therefore possible to enhance the task-dependent regulation of hippocampal network connectivity that supports memory processing using noninvasive stimulation.

【 授权许可】

Unknown