Mitophagy: An Emerging Role in Aging and Age-Associated Diseases

Frontiers in Cell and Developmental Biology

Guido Kroemer²  Guo Chen⁹  Oliver Kepp^1,10 

[1] 0Suzhou Institute for Systems Medicine, Chinese Academy of Sciences, Suzhou, China;1Karolinska Institute, Department of Women’s and Children’s Health, Karolinska University Hospital, Stockholm, Sweden;Equipe 11 Labellisée par la Ligue Nationale Contre le Cancer, Centre de Recherche des Cordeliers, Paris, France;Gustave Roussy Cancer Campus, Villejuif, France;INSERM, UMR 1138, Centre de Recherche des Cordeliers, Paris, France;Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France;Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France;Sorbonne Université, Paris, France;The State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, China;Université Paris-Saclay, Faculté de Médecine, Kremlin-Bicêtre, France;Université de Paris, Paris, France;

关键词: mitophagy;    aging;    mitochondria;    caloric restriction;    ROS;   

DOI  :  10.3389/fcell.2020.00200

来源: DOAJ

【 摘 要 】

Mitochondrial dysfunction constitutes one of the hallmarks of aging and is characterized by irregular mitochondrial morphology, insufficient ATP production, accumulation of mitochondrial DNA (mtDNA) mutations, increased production of mitochondrial reactive oxygen species (ROS) and the consequent oxidative damage to nucleic acids, proteins and lipids. Mitophagy, a mitochondrial quality control mechanism enabling the degradation of damaged and superfluous mitochondria, prevents such detrimental effects and reinstates cellular homeostasis in response to stress. To date, there is increasing evidence that mitophagy is significantly impaired in several human pathologies including aging and age-related diseases such as neurodegenerative disorders, cardiovascular pathologies and cancer. Therapeutic interventions aiming at the induction of mitophagy may have the potency to ameliorate these dysfunctions. In this review, we summarize recent findings on mechanisms controlling mitophagy and its role in aging and the development of human pathologies.

【 授权许可】

Unknown