The Aging Heart: Mitophagy at the Center of Rejuvenation

Frontiers in Cardiovascular Medicine

article

Wenjing J. Liang¹  Åsa B. Gustafsson¹ 

[1] Department of Pharmacology, Department of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California

关键词: aging;    autophagy;    mitophagy;    mitochondria;    heart;    PINK1;    Parkin;    mitophagy receptors;   

DOI  :  10.3389/fcvm.2020.00018

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Aging is associated with structural and functional changes in the heart and is a major risk factor in developing cardiovascular disease. Many recent studies have focused on increasing our understanding of the basis of aging at the cellular and molecular levels in various tissues, including the heart. It is known that there is an age-related decline in cellular quality control pathways such as autophagy and mitophagy, which leads to accumulation of potentially harmful cellular components in cardiac myocytes. There is evidence that diminished autophagy and mitophagy accelerate the aging process, while enhancement preserves cardiac homeostasis and extends life span. Here, we review the current knowledge of autophagy and mitophagy in aging and discuss how age-associated alterations in these processes contribute to cardiac aging and age-related cardiovascular diseases.

【 授权许可】

CC BY