Is it time to reconsider the administration of thiamine alone or in combination with vitamin C in critically ill patients? A meta-analysis of clinical trial studies

Journal of Intensive Care

Saeed Saadat¹  Nafiseh Shokri-mashhadi²  Ali Aliyari²  Mohammad Hossein Rouhani³  Zahra Hajhashemy³ 

[1] Faculty of Mathematics and Natural Sciences, Department of Computer Sciences, Heinrich Heine Universität;Food Security Research Center and Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences;Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences;

关键词: Intensive care unit;    Thiamine;    Vitamin C;    Low-dose hydrocortisone;    Meta-analysis;   

DOI  :  10.1186/s40560-022-00594-8

来源: DOAJ

【 摘 要 】

Highlights Thiamine, co-supplementation of thiamine and vitamin C and co-administration of hydrocortisone, vitamin C and thiamine (HVT) had no significant effect on free days of ventilation and ICU length of stay. HVT could decrease and thiamine supplementation could increase mortality rate in ICU. Co-supplementation of thiamine and vitamin C could decrease SOFA score.

【 授权许可】

Unknown