Antimicrobial Peptides: Diversity, Mechanism of Action and Strategies to Improve the Activity and Biocompatibility In Vivo

Biomolecules

Prashant Kumar¹  Jayachandran N. Kizhakkedathu¹  Suzana K. Straus¹ 

[1] Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada;

关键词: antimicrobial peptides;    mechanism of action;    chemical modification;    delivery systems;    bioconjugation;    biocompatibility;    proteolysis;   

DOI  :  10.3390/biom8010004

来源: DOAJ

【 摘 要 】

Antibiotic resistance is projected as one of the greatest threats to human health in the future and hence alternatives are being explored to combat resistance. Antimicrobial peptides (AMPs) have shown great promise, because use of AMPs leads bacteria to develop no or low resistance. In this review, we discuss the diversity, history and the various mechanisms of action of AMPs. Although many AMPs have reached clinical trials, to date not many have been approved by the US Food and Drug Administration (FDA) due to issues with toxicity, protease cleavage and short half-life. Some of the recent strategies developed to improve the activity and biocompatibility of AMPs, such as chemical modifications and the use of delivery systems, are also reviewed in this article.

【 授权许可】

Unknown