Mechanism of Antimicrobial Peptides: Antimicrobial, Anti-Inflammatory and Antibiofilm Activities

International Journal of Molecular Sciences

Ying Luo¹  Yuzhu Song¹ 

[1] College of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China;

关键词: antibiofilm;    anti-inflammatory;    antimicrobial;    antimicrobial peptides;    mechanism of action;   

DOI  :  10.3390/ijms222111401

来源: DOAJ

【 摘 要 】

Antimicrobial peptides (AMPs) are regarded as a new generation of antibiotics. Besides antimicrobial activity, AMPs also have antibiofilm, immune-regulatory, and other activities. Exploring the mechanism of action of AMPs may help in the modification and development of AMPs. Many studies were conducted on the mechanism of AMPs. The present review mainly summarizes the research status on the antimicrobial, anti-inflammatory, and antibiofilm properties of AMPs. This study not only describes the mechanism of cell wall action and membrane-targeting action but also includes the transmembrane mechanism of intracellular action and intracellular action targets. It also discusses the dual mechanism of action reported by a large number of investigations. Antibiofilm and anti-inflammatory mechanisms were described based on the formation of biofilms and inflammation. This study aims to provide a comprehensive review of the multiple activities and coordination of AMPs in vivo, and to fully understand AMPs to realize their therapeutic prospect.

【 授权许可】

Unknown