Peptides and Peptidomimetics for Antimicrobial Drug Design

Pharmaceuticals

Biljana Mojsoska²  Håvard Jenssen¹ 

[1] id="af1-pharmaceuticals-08-00366">Department of Science, Systems and Models, RoskildeUniversity, Universitetsvej 1, Postboks 260, Roskilde 4000, Denma

关键词: antimicrobial peptides;    mechanism of action;    peptidomimetics;   

DOI  :  10.3390/ph8030366

来源: mdpi

【 摘 要 】

The purpose of this paper is to introduce and highlight a few classes of traditional antimicrobial peptides with a focus on structure-activity relationship studies. After first dissecting the important physiochemical properties that influence the antimicrobial and toxic properties of antimicrobial peptides, the contributions of individual amino acids with respect to the peptides antibacterial properties are presented. A brief discussion of the mechanisms of action of different antimicrobials as well as the development of bacterial resistance towards antimicrobial peptides follows. Finally, current efforts on novel design strategies and peptidomimetics are introduced to illustrate the importance of antimicrobial peptide research in the development of future antibiotics.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.