期刊论文详细信息
Biomarker Research
Metabolic reprogramming in macrophage responses
Jingsong He1  Enfan Zhang1  Xi Huang1  Wen Cao1  Ruyi Xu1  Huiyao Gu1  Zhen Cai1  Haimeng Yan1  Yang Liu1  Jianwei Qu1 
[1] Bone Marrow Transplantation Center, The First Afliated Hospital, School of Medicine, Zhejiang University;
关键词: Macrophages;    Metabolism;    Glycolysis;    Fatty acid synthesis;    Fatty acid oxidation;   
DOI  :  10.1186/s40364-020-00251-y
来源: DOAJ
【 摘 要 】

Abstract Macrophages are critical mediators of tissue homeostasis, with the function of tissue development and repair, but also in defense against pathogens. Tumor-associated macrophages (TAMs) are considered as the main component in the tumor microenvironment and play an important role in tumor initiation, growth, invasion, and metastasis. Recently, metabolic studies have revealeded specific metabolic pathways in macrophages are tightly associated with their phenotype and function. Generally, pro-inflammatory macrophages (M1) rely mainly on glycolysis and exhibit impairment of the tricarboxylic acid (TCA) cycle and mitochondrial oxidative phosphorylation (OXPHOS), whereas anti-inflammatory macrophages (M2) are more dependent on mitochondrial OXPHOS. However, accumulating evidence suggests that macrophage metabolism is not as simple as previously thought. This review discusses recent advances in immunometabolism and describes how metabolism determines macrophage phenotype and function. In addition, we describe the metabolic characteristics of TAMs as well as their therapeutic implications. Finally, we discuss recent obstacles facing this area as well as promising directions for future study.

【 授权许可】

Unknown   

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