Importance of Metabolic Adaptations in Francisella Pathogenesis

Frontiers in Cellular and Infection Microbiology

Charbit, Alain¹  Barel, Monique³  Ziveri, Jason⁵ 

[1] Paris Descartes, Paris, France;et de la Recherche Mé, UniversitéInstitut National de la SantéSorbonne Paris Citédicale U1151 - Centre National de la Recherche Scientifique UMR 8253, Institut Necker-Enfants Malades, Team 11: Pathogenesis of Systemic Infections, Paris, France

关键词: Francisella tularensis;    Metabolism;    Glycolysis;    nutrient uptake;    Virulence.;   

DOI  :  10.3389/fcimb.2017.00096

学科分类：生物科学（综合）

来源: Frontiers

【 摘 要 】

Francisella tularensis is a highly infectious Gram-negative bacterium and the causative agent of the zoonotic disease tularemia. This bacterial pathogen can infect a broad variety of animal species and can be transmitted to humans in numerous ways with various clinical outcomes. Although Francisella possesses the capacity to infect numerous mammalian cell types, the macrophage constitutes the main intracellular niche, used for in vivo bacterial dissemination. To survive and multiply within infected macrophages, Francisella must imperatively escape from the phagosomal compartment. In the cytosol, the bacterium needs to control the host innate immune response and adapt its metabolism to this nutrient-restricted niche. Our laboratory has shown that intracellular Francisella mainly relied on host amino acid as major gluconeogenic substrates and provided evidence that the host metabolism was also modified upon Francisella infection. We will review here our current understanding of how Francisella copes with the available nutrient sources provided by the host cell during the course of infection.

【 授权许可】

CC BY