Optimization of metabolism to improve efficacy during CAR-T cell manufacturing

Journal of Translational Medicine

MingFeng Zhao¹  Xin Jin¹  Rui Sun²  Danni Xie³  Xia Xiong³  Meng Zhang³  Jiaxi Wang³ 

[1] Department of Hematology, Tianjin First Central Hospital, 300192, Tianjin, China;Department of Hematology, Tianjin First Central Hospital, 300192, Tianjin, China;School of Medicine, Nankai University, 300071, Tianjin, China;First Center Clinical College, Tianjin Medical University, 300192, Tianjin, China;

关键词: Metabolism;    CAR-T;    Immunotherapy;    Glycolysis;    OXPHOS;   

DOI  :  10.1186/s12967-021-03165-x

来源: Springer

【 摘 要 】

Chimeric antigen receptor T cell (CAR-T cell) therapy is a relatively new, effective, and rapidly evolving therapeutic for adoptive immunotherapies. Although it has achieved remarkable effect in hematological malignancies, there are some problems that remain to be resolved. For example, there are high recurrence rates and poor efficacy in solid tumors. In this review, we first briefly describe the metabolic re-editing of T cells and the changes in metabolism during the preparation of CAR-T cells. Furthermore, we summarize the latest developments and newest strategies to improve the metabolic adaptability and antitumor activity of CAR-T cells in vitro and in vivo.

【 授权许可】

CC BY