Francisella and Antibodies

Microorganisms

Ales Macela¹  Klara Kubelkova¹ 

[1] Department of Molecular Pathology and Biology, Faculty of Military Health Sciences, University of Defence, 1575 Terebesska, 500 01 Hradec Kralove, Czech Republic;

关键词: natural immunity;    natural antibodies;    B cells;    Francisella tularensis;    intracellular pathogen;   

DOI  :  10.3390/microorganisms9102136

来源: DOAJ

【 摘 要 】

Immune responses to intracellular pathogens depend largely upon the activation of T helper type 1-dependent mechanisms. The contribution of B cells to establishing protective immunity has long been underestimated. Francisella tularensis, including a number of subspecies, provides a suitable model for the study of immune responses against intracellular bacterial pathogens. We previously demonstrated that Francisella infects B cells and activates B-cell subtypes to produce a number of cytokines and express the activation markers. Recently, we documented the early production of natural antibodies as a consequence of Francisella infection in mice. Here, we summarize current knowledge on the innate and acquired humoral immune responses initiated by Francisella infection and their relationships with the immune defense systems.

【 授权许可】

Unknown