Diabetes Mellitus and Hypertension—A Case of Sugar and Salt?

International Journal of Molecular Sciences

Michał Holecki¹  Dagmar-Christiane Fischer²  Marcus Sondermann³  HolgerSven Willenberg³  AndreaMarita Kirsch³  Manuela Bastian⁴ 

[1] Department of Internal, Autoimmune and Metabolic Diseases, Medical Faculty in Katowice, Medical University of Silesia, 40-055 Katowice, Poland;Department of Pediatrics, Rostock University Medical Centre, Rostock, 18057 Rostock, Germany;Division of Endocrinology and Metabolism, Rostock University Medical Center, 18057 Rostock, Germany;Institute for Clinical Chemistry and Laboratory Medicine, Rostock University Medical Center, 18057 Rostock, Germany;

关键词: diabetes mellitus;    hypertension;    adrenal;    glucose;    sodium;    osmolality;   

DOI  :  10.3390/ijms21155200

来源: DOAJ

【 摘 要 】

The majority of patients with diabetes mellitus (DM) have hypertension (HTN). A specific mechanism for the development of HTN in DM has not been described. In the Zucker, Endothel, und Salz (sugar, endothelium, and salt) study (ZEuS), indices of glucose metabolism and of volume regulation are recorded. An analysis of these parameters shows that glucose concentrations interfere with plasma osmolality and that changes in glycemic control have a significant impact on fluid status and blood pressure. The results of this study are discussed against the background of the striking similarities between the regulation of sugar and salt blood concentrations, introducing the view that DM is probably a sodium-retention disorder that leads to a state of hypervolemia.

【 授权许可】

Unknown