Aldosterone-Mediated Sodium Retention Is Reflected by the Serum Sodium to Urinary Sodium to (Serum Potassium)2 to Urinary Potassium (SUSPPUP) Index

Diagnostics

Matthias Haase¹  HolgerS. Willenberg¹  Martin Reincke¹  Matthias Schott²  Evelien Kanaan³  Oliver Vonend³ 

[1] D-40225 Dusseldorf, Germany;Department of Nephrology, University Hospital Dusseldorf, Medical Faculty HHU Dusseldorf;Division for Specific Endocrinology, University Hospital Dusseldorf, Medical Faculty HHU Dusseldorf;

关键词: adrenal;    kidney;    hypertension;    aldosterone;    renin;    hypokalemia;   

DOI  :  10.3390/diagnostics10080545

来源: DOAJ

【 摘 要 】

The serum sodium to urinary sodium ratio divided by the (serum potassium)² to urinary potassium ratio (SUSPPUP formula) reflects aldosterone action. We here prospectively investigated into the usefulness of the SUSPPUP ratio as a diagnostic tool in primary hyperaldosteronism. Parallel measurements of serum and urinary sodium and potassium concentrations (given in mmol/L) in the fasting state were done in 225 patients. Of them, 69 were diagnosed with primary aldosteronism (PA), 102 with essential hypertension (EH), 26 with adrenal insufficiency (AI) and 28 did not suffer from the above-mentioned disorders and were assigned to the reference group (REF). The result of the SUSPPUP formula was highest in the PA group (7.4, 4.2–12.3 L/mmol), followed by EH (3.2, 2.3–4.3 L/mmol), PA after surgery (3.9, 3.0–6.0 L/mmol), REF (3.4 ± 1.4 L/mmol) and AI (2.9 +/– 1.2 L/mmol). The best sensitivity in distinguishing PA from EH was reached by multiplication of the aldosterone to renin-ratio (ARR) with the SUSPPUP formula (92.7% at a cut off > 110 L/mmol), highest specificity was reached by the SUSPPUP determinations (87.2%). The integration of the SUSPPUP ratio into the ARR helps to improve the diagnosis of hyperaldosteronism substantially.

【 授权许可】

Unknown