Physical activity enhances the improvement of body mass index and metabolism by inulin: a multicenter randomized placebo-controlled trial performed in obese individuals

BMC Medicine

Marco A. Gianfrancesco¹  Nicolas Paquot¹  Nicolas Lanthier²  Maxime Van Kerckhoven³  Nathalie M. Delzenne³  Julie Rodriguez³  Patrice D. Cani³  Audrey M. Neyrinck³  Laure B. Bindels³  Edith Renguet⁴  Luc Bertrand⁴  Jean-Paul Thissen⁵  Miriam Cnop⁶ 

[1] Laboratory of Diabetology, Nutrition and Metabolic Disease, Université de Liège;Laboratory of Hepatogastroenterology, Institut de Recherche Expérimentale et Clinique, UCLouvain, Université catholique de Louvain;Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, Université catholique de Louvain;Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain;Pole of Endocrinology, Diabetes and Nutrition, Institut de Recherche Expérimentale et Clinique, UCLouvain, Université catholique de Louvain;ULB Center for Diabetes Research, Université Libre de Bruxelles, and Division of Endocrinology, Erasmus Hospital;

关键词: Obesity;    Gut microbiota;    Prebiotic;    Physical activity;    Metabolism;   

DOI  :  10.1186/s12916-022-02299-z

来源: DOAJ

【 摘 要 】

Abstract Background Dietary interventions targeting the gut microbiota have been proposed as innovative strategies to improve obesity-associated metabolic disorders. Increasing physical activity (PA) is considered as a key behavioral change for improving health. We have tested the hypothesis that changing the PA status during a nutritional intervention based on prebiotic supplementation can alter or even change the metabolic response to the prebiotic. We confirm in obese subjects and in high-fat diet fed mice that performing PA in parallel to a prebiotic supplementation is necessary to observe metabolic improvements upon inulin. Methods A randomized, single-blinded, multicentric, placebo-controlled trial was conducted in obese participants who received 16 g/day native inulin versus maltodextrin, coupled to dietary advice to consume inulin-rich versus -poor vegetables for 3 months, respectively, in addition to dietary caloric restriction. Primary outcomes concern the changes on the gut microbiota composition, and secondary outcomes are related to the measures of anthropometric and metabolic parameters, as well as the evaluation of PA. Among the 106 patients who completed the study, 61 patients filled a questionnaire for PA before and after intervention (placebo: n = 31, prebiotic: n = 30). Except the dietitian (who provided dietary advices and recipes book), all participants and research staff were blinded to the treatments and no advices related to PA were given to participants in order to change their habits. In parallel, a preclinical study was designed combining both inulin supplementation and voluntary exercise in a model of diet-induced obesity in mice. Results Obese subjects who increased PA during a 3 months intervention with inulin-enriched diet exhibited several clinical improvements such as reduced BMI (− 1.6 kg/m2), decreased liver enzymes and plasma cholesterol, and improved glucose tolerance. Interestingly, the regulations of Bifidobacterium, Dialister, and Catenibacterium genera by inulin were only significant when participants exercised more. In obese mice, we highlighted a greater gut fermentation of inulin and improved glucose homeostasis when PA is combined with prebiotics. Conclusion We conclude that PA level is an important determinant of the success of a dietary intervention targeting the gut microbiota. Trial registration ClinicalTrials.gov, NCT03852069 (February 22, 2019 retrospectively registered).

【 授权许可】

Unknown