Bamboo-shaving polysaccharide protects against high-diet induced obesity and modulates the gut microbiota of mice

Journal of Functional Foods

Ying Zhang¹  Guobin Xia²  Yunhong Li³  Yufeng Chen³  Chun Chen³  Lu Jin⁴ 

[1] Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA;Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA;Department of Food Science and Nutrition, School of Biosystems Engineering and Food Science, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang Engineering Center for Food Technology and Equipment, Zhejiang University, Hangzhou 310058, China;School of Medicine, Zhejiang University, Hangzhou 310058, China;

关键词: Bamboo-shaving polysaccharide (BSP);    Prebiotic;    Gut microbiota;    Inflammation;    Obesity;    Insulin resistance;   

DOI  :  

来源: DOAJ

【 摘 要 】

Increasing evidence has shown that gut microbiota plays a critical role in regulating pathogenesis of low-grade inflammation and obesity. Bamboo-shaving polysaccharide (BSP, purity: 80–85%, Mw ≈ 10,000 g/mol) is well known for its immunomodulatory capacity. However, no study has previously investigated the anti-obesity activity of BSP. After high fat diet-fed mice were treated with BSP for 8 weeks, we showed that BSP not only improved community richness and diversity of gut microbiota, but also regulated the composition of gut microbiota. Specifically, mice treated with BSP showed lower ratio of Firmicutes/Bacteroidetes, lower relative abundance of harmful bacteria (Enterobacter and Desulfovibrio) and higher relative abundance of beneficial bacteria (Akkermansia muciniphila and Lactobacillus). Moreover, BSP meliorated intestinal barrier integrity, reduced low-grade inflammation, improved lipid metabolism and ameliorated insulin resistance in obese mice. Our results indicated that BSP could be exploited as prebiotic to protect against obesity and insulin resistance in obese individuals.

【 授权许可】

Unknown