The Role of Antioxidants Supplementation in Clinical Practice: Focus on Cardiovascular Risk Factors

Antioxidants

Daniele Pastori¹  Cristina Nocella¹  Simona Bartimoccia¹  Valentina Castellani¹  Vittoria Cammisotto²  Roberto Carnevale³  Mariangela Peruzzi³  Elena Cavarretta³  Giacomo Frati³  Sebastiano Sciarretta³  Alessandra D’Amico⁴  SMiLe Group⁵  Davide Francomano⁶  Valerio Sanguigni⁶ 

[1] Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy;Department of General Surgery and Surgical Specialty Paride Stefanini, Sapienza University of Rome, 00185 Rome, Italy;Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy;Department of Movement, Human and Health Sciences, University of Rome “Foro Italico”, 00135 Rome, Italy;Faculty of Medicine and Surgery, Sapienza University of Rome, 04100 Latina, Italy;Unit of Internal Medicine and Endocrinology, Madonna delle Grazie Hospital, Velletri, 00049 Rome, Italy;

关键词: oxidative stress;    cardiovascular disease;    antioxidants;    risk factors;    biomarkers;    supplementation;   

DOI  :  10.3390/antiox10020146

来源: DOAJ

【 摘 要 】

Oxidative stress may be defined as an imbalance between reactive oxygen species (ROS) and the antioxidant system to counteract or detoxify these potentially damaging molecules. This phenomenon is a common feature of many human disorders, such as cardiovascular disease. Many of the risk factors, including smoking, hypertension, hypercholesterolemia, diabetes, and obesity, are associated with an increased risk of developing cardiovascular disease, involving an elevated oxidative stress burden (either due to enhanced ROS production or decreased antioxidant protection). There are many therapeutic options to treat oxidative stress-associated cardiovascular diseases. Numerous studies have focused on the utility of antioxidant supplementation. However, whether antioxidant supplementation has any preventive and/or therapeutic value in cardiovascular pathology is still a matter of debate. In this review, we provide a detailed description of oxidative stress biomarkers in several cardiovascular risk factors. We also discuss the clinical implications of the supplementation with several classes of antioxidants, and their potential role for protecting against cardiovascular risk factors.

【 授权许可】

Unknown