Association of influenza infection and vaccination with cardiac biomarkers and left ventricular ejection fraction in patients with acute myocardial infarction

International Journal of Cardiology: Heart & Vasculature

Timothy C. Tan¹  Mohana Kunasekaran²  Eleanor M. Hitchen³  Abrar Ahmad Chughtai⁴  Chandini Raina MacIntyre⁵ 

[1] Corresponding author.;Sydney Medical School, The University of Sydney, Department of Medicine, Westmead Hospital, Australia;School of Medical Sciences, UNSW Medicine, The University of New South Wales, Sydney, New South Wales, Australia;School of Public Health and Community Medicine, UNSW Medicine, The University of New South Wales, Sydney, New South Wales, Australia;Sydney Medical School, The University of Sydney, Department of Medicine, Westmead Hospital, Australia;

关键词: Acute myocardial infarction;    Cardia enzymes;    Troponin;    CK-MB;    Influenza;    Influenza vaccine;   

DOI  :  

来源: DOAJ

【 摘 要 】

Aims: The aim of this study was to examine the association of influenza infection and vaccination with extent of cardiac damage during acute myocardial infarctions (AMIs) as measured by serum biomarkers and left ventricular ejection function (LVEF) in patients. Methods: Post-hoc analysis was performed on data from a prospective case-control study of influenza and AMI, conducted in a tertiary care hospital in Sydney, Australia. We included 275 cases of AMI, aged ≥ 40 years admitted to the cardiology during the study period. Results: Mean and median CK-MB levels were significantly higher among unvaccinated group compared to vaccinated group (p value < 0.05). Troponin levels were also higher among unvaccinated group compared to vaccinated group; although not statistically significant. Troponin and CKMB values were not statistically different among influenza positive cases and influenza negative cases. Large size infarcts were less frequent among vaccinated cases compared to unvaccinated cases (25% vs 35.5%) and were more frequent among influenza positive cases compared to influenza negative cases (35.3% vs 31.5%), however differences were not statistically significant. LVEF was lower among vaccinated cases compared to unvaccinated cases (62.5% vs. 52.8%) and influenza positive cases compared to influenza negative cases (58.8% vs 55.4), however differences were not significant. Conclusion: Lower CKMB levels among vaccinated groups showed that influenza vaccine may have a protective effect against large infarcts, therefore influenza vaccination should be recommended for high risk groups. The study suggests an association of larger infarcts with influenza infection, but larger studies are required to confirm this.

【 授权许可】

Unknown