Pinning down viral proteins: A new prototype for virus-host cell interaction

Frontiers in Microbiology

Yoshitsugu eKojima¹  Akihide Ryo¹ 

[1] Yokohama City University School of Medicine;

关键词: Phosphorylation;    Protein Stability;    Pin1;    Prolyl-isomerazation;   

DOI  :  10.3389/fmicb.2010.00107

来源: DOAJ

【 摘 要 】

Pin1 is an enzyme that specifically catalyzes the cis-trans isomerization of phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif in its substrate proteins. Recent studies demonstrate that stability of several viral proteins is regulated by phosphorylation-dependent prolyl-isomerization by a host factor Pin1. Pin1 is now positioned as an important modulator of the molecular crosstalk between virus and host cells and could be a unique target for anti-virus therapy. This new type of post-translational modification by Pin1 might be involved in the regulation of other viral proteins.

【 授权许可】

Unknown