A Tumor Microenvironment Responsive Nanotheranostics Agent for Magnetic Resonance Imaging and Synergistic Photodynamic Therapy/Photothermal Therapy of Liver Cancer

Frontiers in Chemistry

Mo Deng¹  Yingjun Xie²  Xuewen Zhang²  Nannan Xu³  Yuwan Zhu⁴ 

[1] Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, China;Department of Hepatobiliary and Pancreatic Surgery, The Second Hospital of Jilin University, Changchun, Jilin, China;Department of Radiology, The Second Hospital of Jilin University, Changchun, China;State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS), Changchun, China;

关键词: reactive oxygen species;    nanomaterials;    photodynamic therapy;    photothermal therapy;    magnetic resonance imaging;    manganese oxide;   

DOI  :  10.3389/fchem.2021.650899

来源: DOAJ

【 摘 要 】

Surgery is the main treatment for liver cancer in clinic owing to its low sensitivity to chemotherapy and radiotherapy, but this results in high mortality, recurrence, and metastasis rates. It is a feasible strategy to construct tumor microenvironments activated by nanotheranostics agents for the diagnosis and therapy of liver cancer. This study reports on a nanotheranostic agent (MONs@PDA-ICG) with manganese oxide nanoflowers (MONs) as core and polydopamine (PDA) as shell loading, with ICG as a photosensitizer and photothermal agent. MONs@PDA-ICG can not only produce ROS to kill cancer cells but also exhibit good photothermal performance for photothermal therapy (PTT). Importantly, O2 generated by MONs decomposition can relieve the tumor hypoxia and further enhance the treatment effects of photodynamic therapy (PDT). In addition, the released Mn2+ ions make MONs@PDA-ICG serve as tumor microenvironments responsive to MRI contrast for highly sensitive and specific liver cancer diagnosis.

【 授权许可】

Unknown