Characterizing and Exploiting Tumor Microenvironments to Optimize Treatment Outcomes

Cancers

Claire Meaney¹  Emma H. Allott²  Kellie Dean³  Tracy Robson⁴ 

[1] Department of Mechanical and Automobile Engineering, Limerick Institute of Technology, V94 EC5T Limerick, Ireland;Patrick G. Johnston Centre for Cancer Research, Queen’s University Belfast, Belfast BT9 7AE, UK;School of Biochemistry and Cell Biology, University College Cork, T12 XF62 Cork, Ireland;School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons Ireland, D02 YN77 Dublin, Ireland;

关键词: microenvironment;    immune system;    microbiome;    preclinical models;    organoids;    genetically engineered mouse models;   

DOI  :  10.3390/cancers13225752

来源: DOAJ

【 摘 要 】

Our understanding of cancer initiation, progression, and treatment is continually progressing through dedicated research achieved through laboratory investigation, clinical trials, and patient engagement. The importance and complexity of the microenvironment and its role in tumor development and behavior is pivotal to the understanding of tumor growth and the best course of treatment. The 57th Irish Association for Cancer Research (IACR) Annual Conference collected key researchers, clinicians, and patient advocates together to highlight and discuss the recognized importance of the microenvironment and treatment advances in cancer. In this article, we describe the key components of the microenvironment that influence tumor development and treatment, including the microbiome, metabolism, and immune response and the progress of preclinical models to reflect these complex environments. From a psycho-social oncology perspective, we highlight expert opinion and data on the process of shared decision-making in the context of emerging cancer treatments.

【 授权许可】

Unknown