Biology | |
The Interaction of Viruses with the Cellular Senescence Response | |
Rocío Seoane1  AhmedEl Motiam1  Carmen Rivas1  Santiago Vidal1  YanisHichem Bouzaher1  | |
[1] Centro de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidad de Santiago de Compostela, 15706 Santiago de Compostela, Spain; | |
关键词: senescence; senolytics; virosenolytics; virus; | |
DOI : 10.3390/biology9120455 | |
来源: DOAJ |
【 摘 要 】
Cellular senescence is viewed as a mechanism to prevent malignant transformation, but when it is chronic, as occurs in age-related diseases, it may have adverse effects on cancer. Therefore, targeting senescent cells is a novel therapeutic strategy against senescence-associated diseases. In addition to its role in cancer protection, cellular senescence is also considered a mechanism to control virus replication. Both interferon treatment and some viral infections can trigger cellular senescence as a way to restrict virus replication. However, activation of the cellular senescence program is linked to the alteration of different pathways, which can be exploited by some viruses to improve their replication. It is, therefore, important to understand the potential impact of senolytic agents on viral propagation. Here we focus on the relationship between virus and cellular senescence and the reported effects of senolytic compounds on virus replication.
【 授权许可】
Unknown