The Interaction of Viruses with the Cellular Senescence Response

Biology

Rocío Seoane¹  AhmedEl Motiam¹  Carmen Rivas¹  Santiago Vidal¹  YanisHichem Bouzaher¹ 

[1] Centro de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidad de Santiago de Compostela, 15706 Santiago de Compostela, Spain;

关键词: senescence;    senolytics;    virosenolytics;    virus;   

DOI  :  10.3390/biology9120455

来源: DOAJ

【 摘 要 】

Cellular senescence is viewed as a mechanism to prevent malignant transformation, but when it is chronic, as occurs in age-related diseases, it may have adverse effects on cancer. Therefore, targeting senescent cells is a novel therapeutic strategy against senescence-associated diseases. In addition to its role in cancer protection, cellular senescence is also considered a mechanism to control virus replication. Both interferon treatment and some viral infections can trigger cellular senescence as a way to restrict virus replication. However, activation of the cellular senescence program is linked to the alteration of different pathways, which can be exploited by some viruses to improve their replication. It is, therefore, important to understand the potential impact of senolytic agents on viral propagation. Here we focus on the relationship between virus and cellular senescence and the reported effects of senolytic compounds on virus replication.

【 授权许可】

Unknown