Deletion of SA β‐Gal+ cells using senolytics improves muscle regeneration in old mice

Aging Cell

Zuo Jian Tang¹  Zheng Liu¹  Cory M. Dungan²  Charlotte A. Peterson³  Kevin A. Murach³  Davis A. Englund³  Zachary Hettinger³  Michael Franti⁴  Antonio Filareto⁴  Christopher J. Zdunek⁵  Georgia L. VonLehmden⁵  Camille R. Brightwell⁶  Christopher S. Fry⁶ 

[1] Computational Biology, GCBDS, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, USA;Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, Kentucky, USA;Sanders‐Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA;The Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, USA;Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, Kentucky, USA;The Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, USA;Regenerative Medicine, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, USA;The Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, USA;The Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, USA;Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, Kentucky, USA;

关键词: regeneration;    satellite cells;    senescence;    senolytics;    skeletal muscle;   

DOI  :  10.1111/acel.13528

来源: Wiley

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