Adipokines in young survivors of childhood acute lymphocytic leukemia revisited: beyond fat mass

Annals of Pediatric Endocrinology & Metabolism

Solange Andreoni¹  Gil Guerra-Junior²  Adriana Aparecida Siviero-Miachon³  Angela Maria Spinola-Castro³  Maria Lucia de Martino Lee⁴  Antonio Ramos Calixto⁵  Bruno Geloneze⁵ 

[1] Division of Biostatistics, Department of Preventive Medicine, UNIFESP/EPM, Sao Paulo, Brazil;Division of Pediatric Endocrinology, Faculty of Medical Sciences, UNICAMP, Campinas, Brazil;Division of Pediatric Endocrinology, Federal University of Sao Paulo - UNIFESP/EPM, Sao Paulo, Brazil;Division of Pediatric Oncology - Hospital Santa Marcelina/TUCCA, Sao Paulo, Brazil;Laboratory of I nvestigation on Metabolism and Diabetes - LIMED, Faculty of Medical Sciences, State University of Campinas - UNICAMP, Campinas, Brazil;

关键词: precursor cell lymphoblastic leukemia-lymphoma;    radiotherapy;    complications;    body weight;    adipokines;    adipose tissue;   

DOI  :  10.6065/apem.1938174.087

来源: DOAJ

【 摘 要 】

Purpose This cross-sectional study evaluated the relationship between adipokines (leptin, adiponectin, visfatin, and resistin) and adiposity indexes regarding sex and cranial radiotherapy exposure among young acute lymphocytic leukemia survivors. Methods A multivariate analysis of covariance (MANCOVA) was used to evaluate the joint effect of sex, cranial radiotherapy, and body mass index (BMI) z-score (model 1) or fat mass index (FMI) (model 2) on adipokines. Results This study included 55 survivors of childhood acute lymphocytic leukemia between 15 and 23 years of age from both sexes (56.4% female); 43.6% of the sample had undergone cranial radiotherapy (18–24 Gy). The BMI z-score, the FMI, and sex (P<0.050 for all) influenced at least one adipokine, while cranial radiotherapy exposure was marginal in model 2. Parameter estimates from the MANCOVA's final model showed that the BMI z-score (β=-0.437, P=0.010) and the FMI (β=-0.209, P=0.004) negatively influenced adiponectin, while the FMI positively affected resistin (β=0.142, P=0.020). The relationship between leptin, visfatin, and the adiposity ndexes could not be established. In model 1, females presented with increased adiponectin (β=-1.014, P=0.011) and resistin (β=-1.067, P=0.002) levels; in model 2, female sex positively affected adiponectin (β=-1.515, P=0.001) and marginally influenced resistin (β=-0.707, P=0.054) levels. Cranial radiotherapy negatively determined visfatin levels in both final models (P<0.050). Conclusions Changes in body fat may be associated with adipose tissue dysfunction and should be carefully evaluated in survivors of acute lymphocytic leukemia, considering both sex and cranial radiotherapy exposure, to treat disorders that may possibly aggravate their risk for early cardiovascular disease.

【 授权许可】

Unknown