Iatrogenic Ocular Surface Diseases Occurring during and/or after Different Treatments for Ocular Tumours

Cancers

Vito Romano¹  Vincenzo Scorcia²  Giuseppe Giannaccare²  Antonio Maestri³  Martina Angi⁴  Marco Pellegrini⁵  Federico Bernabei⁶  Pierre-Räphael Rothschild⁶ 

[1] Department of Corneal and External Eye Diseases, St Paul’s Eye Unit, Royal Liverpool University Hospital, Liverpool L7 8XP, UK;Department of Ophthalmology, University Magna Græcia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy;Medical Oncology Department, Santa Maria della Scaletta Hospital, 40026 Imola, Italy;Ocular Oncology Service, Department of Surgical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumouri, 20133 Milan, Italy;Ophthalmology Unit, S.Orsola-Malpighi University Hospital, University of Bologna, 40138 Bologna, Italy;Service d’ophtalmologie, Ophtalmopôle de Paris, Hôpital Cochin, AP-HP, F-75014 Paris, France;

关键词: ocular tumours;    radiotherapy;    anti-cancer agents;    ocular surface;    complications;    dry eye;   

DOI  :  10.3390/cancers13081933

来源: DOAJ

【 摘 要 】

The ocular surface represents a finely regulated system that allows the protection of the eye. It is particularly susceptible to different treatments for intraocular tumours, such as uveal melanoma and conjunctival cancers. Traditionally, the management of ocular tumours depends on the characteristics of the lesion, and is based on a combination of selective surgery, topical chemotherapy, and/or radiotherapy delivered through different mechanisms (e.g., charged-particle radiotherapy or brachytherapy). Possible complications involving the ocular surface range from transient dry eye disease or keratitis up to corneal melting and perforation, which in any case deserve careful evaluation for the risk of permanent sigh-threatening complications. Clinicians involved in the management of these patients must be aware of this risk, in order to reach an early diagnosis and promptly set up an adequate treatment. The present review of the literature will summarize acute and chronic complications affecting the ocular surface following different therapies for the treatment of ocular tumours.

【 授权许可】

Unknown