Whole Blood Metabolomics in Aging Research

International Journal of Molecular Sciences

Mitsuhiro Yanagida¹  Hiroshi Kondoh²  Masahiro Kameda² 

[1] G0 Cell Unit, Okinawa Institute of Science and Technology Graduate University (OIST), Okinawa 904-0495, Japan;Geriatric Unit, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan;

关键词: aging;    metabolites;    frailty;    fasting;    antioxidant;    metabolomics;   

DOI  :  10.3390/ijms22010175

来源: DOAJ

【 摘 要 】

Diversity is observed in the wave of global aging because it is a complex biological process exhibiting individual variability. To assess aging physiologically, markers for biological aging are required in addition to the calendar age. From a metabolic perspective, the aging hypothesis includes the mitochondrial hypothesis and the calorie restriction (CR) hypothesis. In experimental models, several compounds or metabolites exert similar lifespan-extending effects, like CR. However, little is known about whether these metabolic modulations are applicable to human longevity, as human aging is greatly affected by a variety of factors, including lifestyle, genetic or epigenetic factors, exposure to stress, diet, and social environment. A comprehensive analysis of the human blood metabolome captures complex changes with individual differences. Moreover, a non-targeted analysis of the whole blood metabolome discloses unexpected aspects of human biology. By using such approaches, markers for aging or aging-relevant conditions were identified. This information should prove valuable for future diagnosis or clinical interventions in diseases relevant to aging.

【 授权许可】

Unknown