Integrative metabolomics as emerging tool to study autophagy regulation

Microbial Cell

Sarah Stryeck¹  Tobias Madl¹  Ruth Birner-Gruenberger² 

[1] Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, 8010 Graz, Austria.;Research Unit for Functional Proteomics and Metabolic Pathways, Institute of Pathology, Medical University of Graz, 8010 Graz, Aus-tria.;

关键词: metabolomics;    autophagy;    metabolites;    aging;    nuclear magnetic resonance;    mass spectrometry;   

DOI  :  10.15698/mic2017.08.584

来源: DOAJ

【 摘 要 】

Recent technological developments in metabolomics research have enabled in-depth characterization of complex metabolite mixtures in a wide range of biological, biomedical, environmental, agricultural, and nutritional research fields. Nuclear magnetic resonance spectroscopy and mass spectrometry are the two main platforms for performing metabolomics studies. Given their broad applicability and the systemic insight into metabolism that can be ob-tained it is not surprising that metabolomics becomes increasingly popular in basic biological research. In this review, we provide an overview on key me-tabolites, recent studies, and future opportunities for metabolomics in stud-ying autophagy regulation. Metabolites play a pivotal role in autophagy regulation and are therefore key targets for autophagy research. Given the recent success of metabolomics, it can be expected that metabolomics ap-proaches will contribute significantly to deciphering the complex regulatory mechanisms involved in autophagy in the near future and promote under-standing of autophagy and autophagy-related diseases in living cells and or-ganisms.

【 授权许可】

Unknown