Sub–100 nm Nanoparticle Upconcentration in Flow by Dielectrophoretic Forces

Micromachines

Mark Holm Olsen¹  Winnie E. Svendsen²  Maria Dimaki²  Noemi Rozlosnik³ 

[1] Center for Plastics and Packaging Technology, Teknologisk Institut, Gregersensvej 1, 2630 Taastrup, Denmark;DTU Bioengineering, Technical University of Denmark, Søltofts Plads, Bldg 221, 2800 Kongens Lyngby, Denmark;Eir Diagnostics ApS, Muslingevej 36B, 8250 Egå, Denmark;

关键词: dielectrophoresis;    upconcentration;    microfluidics;    nanoparticles;   

DOI  :  10.3390/mi13060866

来源: DOAJ

【 摘 要 】

This paper presents a novel microfluidic chip for upconcentration of sub–100 nm nanoparticles in a flow using electrical forces generated by a DC or AC field. Two electrode designs were optimized using COMSOL Multiphysics and tested using particles with sizes as low as 47 nm. We show how inclined electrodes with a zig-zag three-tooth configuration in a channel of 20 µm width are the ones generating the highest gradient and therefore the largest force. The design, based on AC dielectrophoresis, was shown to upconcentrate sub–100 nm particles by a factor of 11 using a flow rate of 2–25 µL/h. We present theoretical and experimental results and discuss how the chip design can easily be massively parallelized in order to increase throughput by a factor of at least 1250.

【 授权许可】

Unknown