Cytotoxic Tetrahydroxanthone Dimers from the Mangrove-Associated Fungus Aspergillus versicolor HDN1009

Marine Drugs

Guangwei Wu¹  Guojian Zhang¹  Qian Che¹  Tianjiao Zhu¹  Dehai Li¹  Zichao Sun¹  Qianqun Gu¹  Xiaomin Zhang¹  Guihong Yu¹ 

[1] Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China;

关键词: mangrove-derived fungus;    Aspergillus versicolor;    tetrahydroxanthone dimers;    antibacterial activity;    cytotoxicity;   

DOI  :  10.3390/md16090335

来源: DOAJ

【 摘 要 】

Three new tetrahydroxanthone dimers, 5-epi-asperdichrome (1), versixanthones N (2), and O (3), were isolated from the mangrove-derived fungus Aspergillus versicolor HDN1009. Their structures, including the absolute configurations, were elucidated by NMR, HRMS, and circular dichroism (CD) experiments. Among them, compound 1 was the second example of tetrahydroxanthone dimers, which dimerized by a rare diaryl ether linkage and showed promising antibacterial activities against Vibrio parahemolyticus, Bacillus subtilis, Mycobacterium phlei, and Pseudomonas aeruginosa, with MIC values ranging from 100 μM to 200 μM; whilst compounds 2 and 3 exhibited extensive cytotoxicities against five cancer cell lines (HL-60, K562, H1975, MGC803, and HO-8910), with IC50 values ranging from 1.7 μM to 16.1 μM.

【 授权许可】

Unknown