Aspersymmetide A, a New Centrosymmetric Cyclohexapeptide from the Marine-Derived Fungus Aspergillus versicolor

Marine Drugs

Yang Hai¹  Chang-Lun Shao¹  Ya-Hui Zhang¹  Chang-Yun Wang¹  Xue-Mei Hou¹  Ji-Yong Zheng²  Yu-Cheng Gu³ 

[1] Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China;State Key Laboratory for Marine Corrosion and Protection, Luoyang Ship Material Research (LSMRI), Qingdao 266061, China;Syngenta, Jealott’s Hill International Research Centre, Bracknell RG42 6EY, Berkshire, UK;

关键词: gorgonian-derived fungus;    Carijoa sp.;    Aspergillus versicolor;    centrosymmetric cyclohexapeptide;    cytotoxicity;   

DOI  :  10.3390/md15110363

来源: DOAJ

【 摘 要 】

A new centrosymmetric cyclohexapeptide, aspersymmetide A (1), together with a known peptide, asperphenamate (2), was isolated from the fungus Aspergillus versicolor isolated from a gorgonian coral Carijoa sp., collected from the South China Sea. The chemical structure of 1 was elucidated by analyzing its NMR spectroscopy and MS spectrometry data, and the absolute configurations of the amino acids of 1 were determined by Marfey’s method and UPLC-MS analysis of the hydrolysate. Aspersymmetide A (1) represents the first example of marine-derived centrosymmetric cyclohexapeptide. Moreover, 1 exhibited weak cytotoxicity against NCI-H292 and A431 cell lines at the concentration of 10 μM.

【 授权许可】

Unknown