Effect of acupuncture on women with poor ovarian response: a study protocol for a multicenter randomized controlled trial

Trials

Li Chen¹  Cuilian Zhang²  Yang Bai³  Yigong Fang⁴  Huisheng Yang⁴  Yaqian Yin⁴  Chensi Zheng⁴  Li Yang⁴  Mingzhao Hao⁴  Huanfang Xu⁴  Liyun He⁵  Baoyan Liu⁵  Cui Zhao⁶  Fang Zhao⁷  Huidan Wang⁸  Guoqing Tong⁹  Tongsheng Su^1,10  Yu Li^1,11 

[1] East Region Military Command General Hospital;Henan Provincial People’s Hospital;Huazhong University of Science and Technology Reproductive Medicine Center of Tongji Medical College;Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences;Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences;Lanzhou University First Hospital;Luoyang Women and Children Health Care Center;Shandong University Reproductive Hospital;Shanghai Shuguang Hospital;Shanxi Provincial Hospital of Chinese Medicine;Sun Yat-sen Memorial Hospital of the Sun Yat-sen University;

关键词: Acupuncture;    Poor ovarian response;    Number of retrieved oocytes;    In vitro fertilization-embryo transfer;    Randomized controlled trial;   

DOI  :  10.1186/s13063-020-04690-8

来源: DOAJ

【 摘 要 】

Abstract Background Poor ovarian response (POR), a manifestation of low ovarian reserve and ovarian aging, leads to a significant reduction in the pregnancy rate after in vitro fertilization-embryo transfer. Acupuncture has increasingly been used to improve the ovarian reserve. The purpose of this study will be to evaluate the effect of acupuncture on increasing the number of retrieved oocytes after controlled ovarian hyperstimulation in women with POR. Methods This will be a multicenter randomized controlled trial. A total of 140 women with POR will be randomly assigned to receive acupuncture or nontreatment for 12 weeks before controlled ovarian hyperstimulation. The primary outcome will be the number of retrieved oocytes. The secondary outcomes will be antral follicle counts, serum levels of anti-Müllerian hormone, basal serum levels of follicle stimulating hormone, luteinizing hormone and estradiol levels, scores from the self-rating anxiety scale, fertilization rates, cleavage rates, available embryo rates, and high-quality embryo rates. The safety of acupuncture will also be assessed. Discussion The results of this trial will help to determine the effectiveness of acupuncture in the treatment of POR. This may provide a new treatment option for patients with POR and their physicians. Trial registration AMCTR-IPR-18000198 . Registered on 10 August 2018.

【 授权许可】

Unknown