Effects of dysregulated glucose metabolism on the occurrence and ART outcome of endometriosis

European Journal of Medical Research

Research

Yan-Yun Ying¹  Xiao-Hang Ye¹  Huan-Na Tang¹  Jian-Peng Chen¹  Yan-Ye Zhang¹  Yue Ying¹  Qi-Qi Xu¹  Fei-Da Ni¹  Zhi-Min Song¹  Jia-Ni Jin¹  Mi-Xue Tu¹  Dan Zhang²  Jing-Yi Li² 

[1] Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women’s Hospital, Zhejiang University School of Medicine, 310006, Hangzhou, Zhejiang, People’s Republic of China;Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women’s Hospital, Zhejiang University School of Medicine, 310006, Hangzhou, Zhejiang, People’s Republic of China;Zhejiang Provincial Clinical Research Center for Child Health, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, China;

关键词: Endometriosis;    Metabolic indicator;    Number of retrieved oocytes;    ART outcomes;    GDM;   

DOI  :  10.1186/s40001-023-01280-7

 received in 2023-06-14, accepted in 2023-08-10,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundEndometriosis is associated with systemic metabolic indicators, including body mass index (BMI), glucose metabolism and lipid metabolism, while the association between metabolic indexes and the occurrence and assisted reproductive technology (ART) outcome of endometriosis is unclear. We aimed to evaluate the characteristics of systemic metabolic indexes of endometriosis patients with infertility and their effects on pregnancy outcome after ART treatment.MethodsA retrospective cohort study involve 412 endometriosis patients and 1551 controls was conducted. Primary outcome was metabolic indexes, and secondary measures consisted of the influence of metabolic indexes on the number of retrieved oocytes and ART outcomes.ResultsEndometriosis patients had higher insulin (INS) [6.90(5.10–9.50) vs 6.50(4.80–8.90) μU/mL, P = 0.005]. A prediction model for endometriosis combining the number of previous pregnancies, CA125, fasting blood glucose (Glu) and INS, had a sensitivity of 73.9%, specificity of 67.8% and area under curve (AUC) of 0.77. There were no significant differences in ART outcomes and complications during pregnancy. The serum levels of Glu before pregnancy were associated with GDM both in endometriosis group (aOR 12.95, 95% CI 1.69–99.42, P = 0.014) and in control group (aOR 4.15, 95% CI 1.50–11.53, P = 0.006).ConclusionsWe found serum Glu is related to the number of retrieved oocytes in control group, serum INS is related to the number of retrieved oocytes in endometriosis group, while serum Glu and INS before pregnancy are related to the occurrence of GDM in two groups. A prediction model based on metabolic indexes was established, representing a promising non-invasive method to predict endometriosis patients with known pregnancy history.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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