Reference intervals of gestational sac, yolk sac, embryonic length, embryonic heart rate at 6–10 weeks after in vitro fertilization-embryo transfer

BMC Pregnancy and Childbirth

Shuanglin Xiang¹  Yan Ouyang²  Jiabi Qin³  Xihong Li⁴  Ge Lin⁴ 

[1] College of Life Science, Hunan Normal University, Changsha, China;College of Life Science, Hunan Normal University, Changsha, China;Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, China;Clinical Research Center For Reproduction and Genetics in Hunan Province, Changsha, China;Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China;Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, China;Clinical Research Center For Reproduction and Genetics in Hunan Province, Changsha, China;

关键词: Reference interval;    Crown-rump length;    Embryonic heart rate;    Gestational sac;    Yolk sac;    In vitro fertilization-embryo transfer;    First trimester;   

DOI  :  10.1186/s12884-020-03186-2

来源: Springer

【 摘 要 】

BackgroundAccurately determining the normal range of early pregnancy markers can help to predict adverse pregnancy outcomes. The variance in ovulation days leads to uncertain accuracy of reference intervals for natural pregnancies. While the gestational age (GA) is accurate estimation during in vitro fertilization-embryo transfer (IVF-ET). Thus, the objective of this research is to construct reference intervals for gestational sac diameter (GSD), yolk sac diameter (YSD), embryonic length (or crown–rump length, CRL) and embryonic heart rate (HR) at 6–10 gestational weeks (GW) after IVF-ET.MethodsFrom January 2010 to December 2016, 30,416 eligible singleton pregnancies were retrospectively recruited. All included participants had full records of early ultrasound measurements and phenotypically normal live neonates after 37 GW, with birth weights > the 5th percentile for gestational age. The curve-fitting method was used to screen the optimal models to predict GSD, CRL, YSD and HR based on gestational days (GD) and GW. Additionally, the percentile method was used to calculate the 5th, 50th, and 95th percentiles.ResultsThere were significant associations among GSD, CRL, YSD, HR and GD and GW, the models were GSD = − 29.180 + 1.070 GD (coefficient of determination [R2] = 0.796), CRL = − 11.960 - 0.147 GD + 0.011 GD2 (R2 = 0.976), YSD = − 2.304 + 0.184 GD - 0.011 GD2 (R2 = 0.500), HR = − 350.410 + 15.398 GD - 0.112 GD2 (R2 = 0.911); and GSD = − 29.180 + 7.492 GW (R2 = 0.796), CRL = − 11.960 - 1.028 GW + 0.535 GW2 (R2 = 0.976), YSD = − 2.304 + 1.288 GW - 0.054 GW2 (R2 = 0.500), HR = − 350.410 + 107.788 GW - 5.488 GW2 (R2 = 0.911), (p < 0.001).ConclusionsReference intervals for GSD, YSD, HR and CRL at 6–10 gestational weeks after IVF-ET were established.

【 授权许可】

CC BY