The effects of microgravity on differentiation and cell growth in stem cells and cancer stem cells

Stem Cells Translational Medicine

Marcus Krüger¹  Markus Wehland¹  Sascha Kopp¹  Michael Lebert²  Peter Richter²  Binod Prasad²  Thomas J. Corydon³  Daniela Grimm⁴  Marcel Egli⁵  Johann Bauer⁶ 

[1] Clinic for Plastic, Aesthetic and Hand Surgery Otto von Guericke University Magdeburg Germany;Department of Biology Friedrich‐Alexander‐University Erlangen‐Nuremberg Erlangen Germany;Department of Biomedicine Aarhus University Aarhus Denmark;Department of Microgravity and Translational Regenerative Medicine Otto von Guericke University Magdeburg Germany;Institute of Medical Engineering, Space Biology Group Lucerne University of Applied Sciences and Arts Hergiswil Switzerland;Max Planck Institute of Biochemistry Planegg‐Martinsried Germany;

关键词: cancer stem cells;    microgravity;    multicellular spheroids;    organoids;    random positioning machine;    rotating wall vessel;   

DOI  :  10.1002/sctm.20-0084

来源: DOAJ

【 摘 要 】

Abstract A spaceflight has enormous influence on the health of space voyagers due to the combined effects of microgravity and cosmic radiation. Known effects of microgravity (μg) on cells are changes in differentiation and growth. Considering the commercialization of spaceflight, future space exploration, and long‐term manned flights, research focusing on differentiation and growth of stem cells and cancer cells exposed to real (r‐) and simulated (s‐) μg is of high interest for regenerative medicine and cancer research. In this review, we focus on platforms to study r‐ and s‐μg as well as the impact of μg on cancer stem cells in the field of gastrointestinal cancer, lung cancer, and osteosarcoma. Moreover, we review the current knowledge of different types of stem cells exposed to μg conditions with regard to differentiation and engineering of cartilage, bone, vasculature, heart, skin, and liver constructs.

【 授权许可】

Unknown