A Microfluidic Multisize Spheroid Array for Multiparametric Screening of Anticancer Drugs and Blood–Brain Barrier Transport Properties

Advanced Science

Winfried Neuhaus¹  Anna Gerhartl¹  Christoph Eilenberger²  Michael Harasek²  Florian Selinger²  Christian Jordan²  Peter Ertl²  Mario Rothbauer³  Seta Küpcü⁴  Barbara Schädl⁵  Johannes Grillari⁶  Julian Weghuber⁷ 

[1] AIT Austrian Institute of Technology GmbH, Center Health and Bioresources, Competence Unit Molecular Diagnostics, Giefinggasse 4, Vienna, 1210, Austria;Faculty of Technical Chemistry, Vienna University of Technology, Getreidemarkt 9, Vienna, 1060, Austria;Faculty of Technical Chemistry, Vienna University of Technology, Getreidemarkt 9, Vienna, 1060, Austria;Karl Chiari Lab for Orthopaedic Biology, Department of Orthopedics and Trauma Surgery, Medical University of Vienna, Währinger Gürtel 18‐20, Vienna, 1090, Austria;Institute of Synthetic Bioarchitectures, Department of Nanobiotechnology, University of Natural Resources and Life Sciences, Vienna, Muthgasse 11, Vienna, 1190, Austria;Ludwig‐Boltzmann‐Institute for Experimental and Clinical Traumatology, Donaueschingenstraße 13, Vienna, 1200, Austria;Ludwig‐Boltzmann‐Institute for Experimental and Clinical Traumatology, Donaueschingenstraße 13, Vienna, 1200, Austria;Institute for Molecular Biotechnology, Department of Biotechnology, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna, 1190, Austria;School of Engineering, University of Applied Sciences Upper Austria, Stelzhamerstraße 23, Wels, 4600, Austria;FFoQSI GmbH‐Austrian Competence Centre for Feed and Food Quality, Safety and Innovation, Technopark 1C, Tulln, 3430, Austria;

关键词: anticancer drugs;    blood‐brain barrier;    in vitro tests;    microfluidics;    multicellular spheroids;   

DOI  :  10.1002/advs.202004856

来源: Wiley

【 授权许可】

CC BY