Cross-talks between natural killer cells and distinct subsets of dendritic cells

Frontiers in Immunology

Guido eFerlazzo¹  Barbara eMorandi² 

[1] Cellular Therapy Program, University Hospital - A.O.U. Policlinico;Department of Experimental Medicine Universiy of Genoa;Department of Human Pathology, University of Messina;

关键词: Cross-Priming;    Dendritic Cells;    Humans;    Natural Killer cells;    Th1 polarization;   

DOI  :  10.3389/fimmu.2014.00159

来源: DOAJ

【 摘 要 】

In recent years, the essential role of bidirectional cross-talk between natural killer (NK) and dendritic cells (DC) during immune responses has been clearly elucidated. In particular, this cross-talk results in the development of an efficient innate response, through DC-mediated NK cell activation, and a potent adaptive immune response, through NK-mediate DC editing and maturation.
Recently, some novel human DC subsets have been identified: migratory DCs in afferent lymph and draining lymph nodes; CLEC9A+/ BDCA3+ DCs in interstitial dermis, liver, lung; inflammatory DCs in several fluids secondary to flogosis. At the same time, it has been shown that also human NK cells are present in these compartments.
Here we will review the most recent findings on NK/DC cross-talk and we will discuss the necessity of acquiring more complete knowledge about these interactions in view of the new information available on both DC and NK cell subsets.

【 授权许可】

Unknown