Plasma Nitrate and Pteridine Levels in Experimental Bacteremia in Baboons

Pteridines

Werner Ernst R.¹  Wachter Helmut¹  Schlag Gunther²  Strohmaier Wolfgang²  Redl Heinz² 

[1] Department of Medical Chemistry and Biochemistry, University of Innsbruck, A-6020 Innsbruck, Austria;Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Donaueschingenstrabe 13, A-1200 Vienna, Austria;

关键词: sepsis;    nitric oxide;    cytokines;    neopterin;    biopterin;   

DOI  :  10.1515/pteridines.1995.6.1.8

来源: DOAJ

【 摘 要 】

Using a recently developed model of bacterially induced sepsis in baboons, we studied the time courses of pteridine and nitrate levels in plasma with regard to the dose of Escherichia coli. Eight animals were given a 2 h infusion of 2X 10" Colony Forming Units live E. coli/kg BW (group LOW), and six others 2X 10" CFU/kg BW (group HIGH). Endotoxin levels and, consequently, the TNF-a, IL-8, and IL-6 concentrations clearly corresponded with the infused amount of live E. coli. The neopterin/creatinine ratio increased in both groups up to 24 h, but was more pronounced in the HIGH group. In contrast, the biopterin/creatinine ratio increased in the HIGH group, but remained unchanged in the LOW group. Plasma nitrate levels remained at baseline (::::: 20 Ilmol!l) up to 4 h, but then increased three- to fourfold within the next 4 h and remained elevated in the HIGH group. In group LOW, the concentrations were unchanged throughout the observation period.

【 授权许可】

Unknown