Glucocorticoids Influencing Wnt/β-Catenin Pathway; Multiple Sites, Heterogeneous Effects

Molecules

Attila Patocs¹  Katalin Meszaros¹ 

[1] Hereditary Tumours Research Group, 1089 Budapest, Hungary;

关键词: glucocorticoid excess;    wnt/β-catenin pathway;    bone;    adipose tissue;    brain;    skin;   

DOI  :  10.3390/molecules25071489

来源: DOAJ

【 摘 要 】

Glucocorticoid hormones are vital; their accurate operation is a necessity at all ages and in all life situations. Glucocorticoids regulate diverse physiological processes and they use many signaling pathways to fulfill their effect. As the operation of these hormones affects many organs, the excess of glucocorticoids is actually detrimental to the whole human body. The endogenous glucocorticoid excess is a relatively rare condition, but a significant proportion of adult people uses glucocorticoid medication for the treatment of chronic illnesses, therefore they are exposed to the side effects of long-term glucocorticoid treatment. Our review summarizes the adverse effects of glucocorticoid excess affecting bones, adipose tissue, brain and skin, focusing on those effects which involve the Wnt/β-catenin pathway.

【 授权许可】

Unknown