Ganoderma lucidum polysaccharides improve insulin sensitivity by regulating inflammatory cytokines and gut microbiota composition in mice

Journal of Functional Foods

J. Guo¹  B. Ye²  X. Rong³  S. Xu³  Q. Wu³  F. Ma⁴  Y. Wang⁴  M. Hu⁴  Y. Dou⁵ 

[1] Corresponding authors at: Guangdong Metabolic Diseases Research Centre of Integrated Chinese, and Western Medicine, Institute of Chinese Medicine Sciences, Guangdong Pharmaceutical University, Guangzhou 510006, China.;Department of Nursing, Medical College of Jiaying University, Meizhou 514031, China;Guangdong Metabolic Diseases Research Centre of Integrated Chinese and Western Medicine, Institute of Chinese Medicine Sciences, Guangdong Pharmaceutical University, Guangzhou, China;Infinitus Chinese Herbal Immunity Research Centre, Guangzhou, China;School of Chinese Meteria Medica, Guangzhou University of Chinese Medicine, Guangzhou, China;

关键词: Ganoderma lucidum polysaccharides;    Insulin resistance;    Gut microbiota;    Type 2 diabetes;    Inflammatory cytokines;   

DOI  :  

来源: DOAJ

【 摘 要 】

Ectopic lipid accumulation and low-grade chronic inflammation are critical pathogenesis of insulin resistance development. Ganoderma lucidum is a traditional Chinese herb for balancing energy homeostasis. In this research, we determined the effects of G. lucidum polysaccharides (GLP) on high-fat diet (HFD)-induced insulin resistant mice. We observed that GLP treatment decreased plasma insulin concentration and reversed HFD-induced systemic insulin resistance. Meanwhile, GLP ameliorated low-grade chronic inflammation, inducing lipolysis in adipose tissues. GLP decreased plasma triglyceride and non-esterified fatty acid outflux by suppressing mRNA expressions of hormone-sensitive lipase, fatty acid binding protein 4, tumor necrosis factor-α, and interleukin-6 in epididymal fat. Finally, GLP treatment suppressed ectopic lipid accumulation in peripheral tissues and hepatic insulin-regulated lipogenesis. GLP also regulated composition of gut microbiota implicated in type 2 diabetes mellitus development.

【 授权许可】

Unknown