Research Progress on Cell Membrane-Coated Biomimetic Delivery Systems

Frontiers in Bioengineering and Biotechnology

Zhipeng Chen²  Chenjie Xia²  Mengyu Guo²  Yu Wu²  Weidong Li²  Nong Zhou³ 

[1] College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China;Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing, China;The Chongqing Engineering Laboratory for Green Cultivation and Deep Processing of Three Gorges Reservoir Area’s Medicinal Herbs, College of Food and Biology Engineering, Chongqing Three Gorges University, Chongqing, China;

关键词: cell membrane;    biomimetic;    drug delivery;    nanomedicine;    nanobiotechnology;   

DOI  :  10.3389/fbioe.2021.772522

来源: DOAJ

【 摘 要 】

Cell membrane-coated biomimetic nanoplatforms have many inherent properties, such as bio-interfacing abilities, self-identification, and signal transduction, which enable the biomimetic delivery system to escape immune clearance and opsonization. This can also maximize the drug delivery efficiency of synthetic nanoparticles (NPs) and functional cell membranes. As a new type of delivery system, cell membrane-coated biomimetic delivery systems have broadened the prospects for biomedical applications. In this review, we summarize research progress on cell membrane biomimetic technology from three aspects, including sources of membrane, modifications, and applications, then analyze their limitations and propose future research directions.

【 授权许可】

Unknown